- AliceO2: The framework and detector specific code for the reconstruction, calibration and simulation for the ALICE experiment at CERN.
- Beam: A scalable, confidential cryptocurrency based on the Mimblewimble protocol.
- BIND 9: DNS software system including an authoritative server, a recursive resolver and related utilities.
- cjdns: Encrypted self-configuring network/VPN routing engine
- clearskies_core: Clearskies file synchronization program. (C++11)
- CMake open-source, cross-platform family of tools designed to build, test and package software
- Cocos-Engine: The runtime framework for Cocos Creator editor.
- Coherence: Cryptographic server for modern web apps.
- DPS8M: GE ∕ Honeywell ∕ Bull DPS‑8/M and 6180/L68 mainframe simulator.
- DPS-For-IoT: Fully distributed publish/subscribe protocol.
- HashLink: Haxe run-time with libuv support included.
- Haywire: Asynchronous HTTP server.
- H2O: An optimized HTTP server with support for HTTP/1.x and HTTP/2.
- Igropyr: a async Scheme http server base on libuv.
- Julia: Scientific computing programming language
- Kestrel: web server (C# + libuv + ASP.NET Core)
- Knot DNS Resolver: A minimalistic DNS caching resolver
- Lever: runtime, libuv at the 0.9.0 release
- libnode: C++ implementation of Node.js
- libstorj: Library for interacting with Storj network
- libuv_message_framing Message-based communication for libuv
- luaw: Lua web server backed by libuv
- Luvit: Node.JS for the Lua Inventor
- mo: Scheme (guile) + libuv runtime
- MoarVM: a VM for Rakudo Raku
- Mysocks: a cross-platform Shadowsocks client
- mediasoup: Powerful WebRTC SFU for Node.js
- Neovim: A major refactor of Vim.
- node9: A portable, hybrid, distributed OS based on Inferno, LuaJIT and Libuv
- node.js: Javascript (using Google's V8) + libuv
- node.native: node.js-like API for C++11
- nodeuv: An organization with several c++ wrappers for libs which are used in node.js.
- phastlight: Command line tool and web server written in PHP 5.3+ inspired by Node.js
- pilight: home automation ("domotica")
- pixie: clojure-inspired lisp with a tracing JIT
- Pixie-io: Open-source observability tool for Kubernetes applications.
- potion/p2: runtime
- racer: Ruby web server written as an C extension
- Socket Runtime: A runtime for creating native cross-platform software on mobile and desktop using HTML, CSS, and JavaScript
- spider-gazelle: Ruby web server using libuv bindings
- Suave: A simple web development F# library providing a lightweight web server and a set of combinators to manipulate route flow and task composition
- Swish: Concurrency engine with Erlang-like concepts. Includes a web server.
- Trevi: A powerful Swift Web Application Server Framework Project
- Urbit: runtime
- uv_callback libuv thread communication
- uvloop: Ultra fast implementation of python's asyncio event loop on top of libuv
- WPILib: Libraries for creating robot programs for the roboRIO.
- Wren CLI: For io, process, scheduler and timer modules
- libtuv: libuv fork for IoT and embedded systems