How To Improve Binder Design in Silico Success Rate? #177
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xinran1129305
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Hi there.
I got around 150 binder designs(backbones)of a specific target protein, but none of the designs meet the requirement of pAE<10. I tried different hotspot and length of binder, but they didn't work out and just remained pAE~26(some of them could reach 19). In this way, what can I do to improve the success rate of designing?
Thanks in advance!!
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